It appears to act on the precapillary sphincter in the stria vascularis of the inner ear, thus reducing the pressure in the endolymphatic space. Primarily, it has a direct stimulating (agonistic) effect on H1 receptors located on blood vessels in the inner ear.
The active ingredient is a specific histamine agonist with virtually no H2-activity.īetago has two modes of action. Betago has a very strong affinity as an antagonist for histamine H3 receptors and a weak affinity as an agonist for histamine H1 receptors.
The mechanism of action of betahistine is known partially.
